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lps ag490 group  (MedChemExpress)


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    MedChemExpress lps ag490 group
    Fig. 5 SPRC inhibited the JAK/STAT signaling pathway in vitro. (A) GSEA revealed significant enrichment of the JAK/STAT signaling pathway. (B-C) Western blot analysis of phosphorylated STAT3 (p-STAT3), total STAT3, phosphorylated JAK2 (p-JAK2), and total JAK2. (D) RT-qPCR analysis of Inos expression. (E-F) Western blot analysis of iNOS protein levels. The data were analyzed via one-way ANOVA (n ≥ 3). Statistical significance is denoted as follows: ###p < 0.001 compared with the control group; *p < 0.05, **p < 0.01, ***p < 0.001 compared with the LPS group; &&&p < 0.001 compared with the LPS + <t>AG490</t> group
    Lps Ag490 Group, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 219 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lps ag490 group/product/MedChemExpress
    Average 96 stars, based on 219 article reviews
    lps ag490 group - by Bioz Stars, 2026-06
    96/100 stars

    Images

    1) Product Images from "S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling."

    Article Title: S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling.

    Journal: Molecular medicine (Cambridge, Mass.)

    doi: 10.1186/s10020-025-01186-6

    Fig. 5 SPRC inhibited the JAK/STAT signaling pathway in vitro. (A) GSEA revealed significant enrichment of the JAK/STAT signaling pathway. (B-C) Western blot analysis of phosphorylated STAT3 (p-STAT3), total STAT3, phosphorylated JAK2 (p-JAK2), and total JAK2. (D) RT-qPCR analysis of Inos expression. (E-F) Western blot analysis of iNOS protein levels. The data were analyzed via one-way ANOVA (n ≥ 3). Statistical significance is denoted as follows: ###p < 0.001 compared with the control group; *p < 0.05, **p < 0.01, ***p < 0.001 compared with the LPS group; &&&p < 0.001 compared with the LPS + AG490 group
    Figure Legend Snippet: Fig. 5 SPRC inhibited the JAK/STAT signaling pathway in vitro. (A) GSEA revealed significant enrichment of the JAK/STAT signaling pathway. (B-C) Western blot analysis of phosphorylated STAT3 (p-STAT3), total STAT3, phosphorylated JAK2 (p-JAK2), and total JAK2. (D) RT-qPCR analysis of Inos expression. (E-F) Western blot analysis of iNOS protein levels. The data were analyzed via one-way ANOVA (n ≥ 3). Statistical significance is denoted as follows: ###p < 0.001 compared with the control group; *p < 0.05, **p < 0.01, ***p < 0.001 compared with the LPS group; &&&p < 0.001 compared with the LPS + AG490 group

    Techniques Used: In Vitro, Western Blot, Quantitative RT-PCR, Expressing, Control



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    lps ag490 group  (MedChemExpress)
    96
    MedChemExpress lps ag490 group
    Fig. 5 SPRC inhibited the JAK/STAT signaling pathway in vitro. (A) GSEA revealed significant enrichment of the JAK/STAT signaling pathway. (B-C) Western blot analysis of phosphorylated STAT3 (p-STAT3), total STAT3, phosphorylated JAK2 (p-JAK2), and total JAK2. (D) RT-qPCR analysis of Inos expression. (E-F) Western blot analysis of iNOS protein levels. The data were analyzed via one-way ANOVA (n ≥ 3). Statistical significance is denoted as follows: ###p < 0.001 compared with the control group; *p < 0.05, **p < 0.01, ***p < 0.001 compared with the LPS group; &&&p < 0.001 compared with the LPS + <t>AG490</t> group
    Lps Ag490 Group, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/lps ag490 group/product/MedChemExpress
    Average 96 stars, based on 1 article reviews
    lps ag490 group - by Bioz Stars, 2026-06
    96/100 stars
    		  Buy from Supplier

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    Fig. 5 SPRC inhibited the JAK/STAT signaling pathway in vitro. (A) GSEA revealed significant enrichment of the JAK/STAT signaling pathway. (B-C) Western blot analysis of phosphorylated STAT3 (p-STAT3), total STAT3, phosphorylated JAK2 (p-JAK2), and total JAK2. (D) RT-qPCR analysis of Inos expression. (E-F) Western blot analysis of iNOS protein levels. The data were analyzed via one-way ANOVA (n ≥ 3). Statistical significance is denoted as follows: ###p < 0.001 compared with the control group; *p < 0.05, **p < 0.01, ***p < 0.001 compared with the LPS group; &&&p < 0.001 compared with the LPS + AG490 group

    Journal: Molecular medicine (Cambridge, Mass.)

    Article Title: S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling.

    doi: 10.1186/s10020-025-01186-6

    Figure Lengend Snippet: Fig. 5 SPRC inhibited the JAK/STAT signaling pathway in vitro. (A) GSEA revealed significant enrichment of the JAK/STAT signaling pathway. (B-C) Western blot analysis of phosphorylated STAT3 (p-STAT3), total STAT3, phosphorylated JAK2 (p-JAK2), and total JAK2. (D) RT-qPCR analysis of Inos expression. (E-F) Western blot analysis of iNOS protein levels. The data were analyzed via one-way ANOVA (n ≥ 3). Statistical significance is denoted as follows: ###p < 0.001 compared with the control group; *p < 0.05, **p < 0.01, ***p < 0.001 compared with the LPS group; &&&p < 0.001 compared with the LPS + AG490 group

    Article Snippet: In the LPS + AG490 group, cells were pretreated with 50 μM AG490 (MedChemExpress, HY-12000, USA) for 1 h, followed by stimulation with LPS for 24 h. In the LPS + SPRC + AG490 group, cells were pretreated with 50 μM AG490 and 100 μM SPRC for 1 h and then stimulated with LPS for 24 h. Rat primary condylar chondrocytes (rPCCs) extraction and culture Rat primary condylar chondrocytes (rPCCs) were isolated from 3-week-old female Sprague-Dawley (SD) rats obtained from the Guangdong Medical Laboratory Animal Center, following a previously established protocol (Yang et al. 2024a, b).

    Techniques: In Vitro, Western Blot, Quantitative RT-PCR, Expressing, Control